Focused on Life

Providing new therapies to care-givers for diseases that currently have few or no treatment options with the aim to improve the lives of those faced with rare diseases with high unmet medical needs

Management Team

General Manager and Site Leader

Mr. Salvatore Calabrese serves as General Manager and Site Leader of Gentium S.p.A., which became a Jazz Pharmaceuticals company in January 2014. Mr. Calabrese had served as Senior Vice President of Finance, Chief Financial Officer and Chief Operating Officer of Gentium since 2010 and as Vice President of Finance since February 2005. From December 2003 to February 2005, he was an Accounting and Finance Manager for Novuspharma, S.p.A., a development stage biopharmaceutical company focused on the discovery and development of cancer drugs and a subsidiary of Cell Therapeutics, Inc., where he was responsible for cost containment, budgeting, financial reporting and the implementation of Sarbanes-Oxley compliance. From September 1996 to November 2003, Mr. Calabrese was employed by PricewaterhouseCoopers as an accountant and was a Manager in Assurance Business Advisory Services at the time of departure. From October 2000 to June 2003, Mr. Calabrese worked in the Boston, MA office of PricewaterhouseCoopers. He earned a bachelors' degree in economics at the University of Messina and a masters' degree in accounting, audit and financial control at the University of Pavia. He is also a chartered accountant in the Republic of Italy.

Vice President, Clinical Science

Dr. Maria Ballabio has served as Vice President, Clinical Science of Gentium S.p.A. since November 2013 and as Head of Medical Science since July 2012. She has over twenty years of experience in the pharmaceutical and biotechnology field, with a primary focus on clinical research and development in different therapeutic areas. Prior to joining Gentium, she worked for a number of pharmaceutical companies, including Edmond Pharma, Chiesi Farmaceutici, Nicox, Italfarmaco, Ipsen, UpsaMedica and Byk Gulden. Dr. Ballabio is a co-author of multiple scientific papers. She earned a bachelor’s degree in medicine at the University of Milan, a post-graduate degree in endocrinology at the University of Pavia and a Ph.D. in endocrinology at the University College and Middlesex School of Medicine in London.

Head of Manufacturing and Maintenance

Mr. Luigi Cislaghi has served as Head of Manufacturing and Maintenance of Gentium S.p.A. since May 2008. He joined Gentium as Plant Manager in 1999 and has contributed to the revamping of the manufacturing plant and multiple inspections by the Italian Health Authority. From 1994 to 1999, Mr. Cislaghi was responsible for the farmacokinetics and clinical development at PCD. From 1988 to 1994, he worked at Edmond Pharma as Head of Manufacturing and Quality Control. From 1980 to 1988, he was an analyst in the chemistry laboratory at Crinos S.p.A.

Vice President, Finance

Ms. Roberta Grandini has served as Vice President, Finance of Gentium S.p.A. since March 2011 and she joined Gentium as an Accounting and Finance Manager in September 2005. Ms. Grandini’s responsibilities include internal control, budget, reporting, financial reporting, U.S. gaap and tax. From 2000 to 2005, she was the Financial Controller for Novuspharma S.p.A., a development stage biopharmaceutical company focused on the discovery and development of cancer drugs and a subsidiary of Cell Therapeutics, Inc. From 1997 to 2000, Ms. Grandini was with KPMG. She earned a bachelor’s degree in Economics at the Cattolic University of Milan.

Drug Safety Manager and European Qualified Person Responsible for Pharmacovigilance (QPPV)

Mr. Marco Sardella has served as European Qualified Person Responsible for Pharmacovigilance (QPPV) and Drug Safety Manager of Gentium S.p.A. since March 2009. He is in charge of the development and implementation of Gentium’s Pharmacovigilance and Risk Management Systems. From November 2006 to February 2009, he was a Deputy European QPPV and Drug safety Specialist involved with the maintenance of the Marketing Authorization and with the management of drug safety sponsored clinical trials and compassionate use programmes. Mr. Sardella received several certifications in Drug Safety and Pharmacovigilance from Regulatory Authorities and International Associations. He is also member of the International Pharmacovigilance Society. He earned a bachelor’s degree in Pharmaceutical Chemistry and Technologies at the University of Sassari (Italy) and is a certified Pharm.D.

Vice President, Regulatory Affairs Europe

Ms. Paola Tocchetti has served as Vice President, Regulatory Affairs Europe of Gentium S.p.A. since November 2013. She joined Gentium as Head of Regulatory Affairs Europe in March 2012. Ms. Tocchetti is responsible for the maintenance of the European Marketing Authorization. She is also a member of the Global Regulatory Affairs of Jazz Pharmaceuticals with the specific role of Defitelio Lead for the International Regulatory Affairs Department and for the global expansion of Defitelio outside of the United States. Ms. Tocchetti has over twenty years of experience in the pharmaceutical and biotechnology field and worked in different roles and position at for NicOx, Zambon, Pharmacia & Upjohn and Farmitalia Carlo Erba. She earned a bachelor’s degree in Biologia Science at the University of Milan.

Vice President Quality, Qualified Person

Mr. Terenzio Ignoni has served as our Vice President Quality since January 2011 and as Quality Manager since January 2007. From April 2005 to December 2006, as Quality Control Manager, he was in charge of the development and implementation of the Quality Control Department of Gentium SpA which was audited, approved and officially authorized by the Italian Regulatory Agency in February 2007. From September 2002 to March 2005 he was analytical development manager at Zambon Group, facility of Almisano di Lonigo, Italy. From March 2001 to September 2002 he worked in the Quality Control of Biosearch Manufacturing, company specialized in the research, development and manufacturing of antibiotics and antifungal agents. He obtained a degree in Pharmaceutical chemistry and technologies at the University of Turin, Italy. He is also certified Qualified Person according to EU Directive 2001/83/EC and related amendment.